Reactome | Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

Stable Identifier

R-HSA-9606151

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

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Phosphorylated BLNK (also called BASH or SLP-65) at the plasma membrane recruits BTK, PLC gamma, VAV, GRB2, and NCK (Fu and Chan 1997, Fu et al. 1998, Wienands et al. 1998, Su et al. 1999, Baba et al. 2001, Chiu et al. 2002). The SH2 domain of BTK binds phosphorylated BLNK (Hashimoto et al. 1999, Su et al. 1999, Baba et al. 2001). BLNK is constitutively bound to CIN85 and phosphorylated BLNK is bound to a large complex containing CIN85, SOS1, GRB2, phosphorylated SYK, and the B cell receptor.

Literature References

PubMed ID	Title	Journal	Year
9705962	SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation Wienands, J, Schweikert, J, Wollscheid, B, Jumaa, H, Nielsen, PJ, Reth, M	J Exp Med	1998
10556826	Interaction of SLP adaptors with the SH2 domain of Tec family kinases Su, YW, Zhang, Y, Schweikert, J, Koretzky, GA, Reth, M, Wienands, J	Eur. J. Immunol.	1999
11226282	BLNK mediates Syk-dependent Btk activation Baba, Y, Hashimoto, S, Matsushita, M, Watanabe, D, Kishimoto, T, Kurosaki, T, Tsukada, S	Proc Natl Acad Sci U S A	2001
10498607	Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling Hashimoto, S, Iwamatsu, A, Ishiai, M, Okawa, K, Yamadori, T, Matsushita, M, Baba, Y, Kishimoto, T, Kurosaki, T, Tsukada, S	Blood	1999
12456653	BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins Chiu, CW, Dalton, M, Ishiai, M, Kurosaki, T, Chan, AC	EMBO J	2002
9697839	BLNK: a central linker protein in B cell activation Fu, C, Turck, CW, Kurosaki, T, Chan, AC	Immunity	1998
21822214	The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 Oellerich, T, Bremes, V, Neumann, K, Bohnenberger, H, Dittmann, K, Hsiao, HH, Engelke, M, Schnyder, T, Batista, FD, Urlaub, H, Wienands, J	EMBO J	2011