Reactome | p-SYK and LYN phosphorylate BTK

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p-SYK and LYN phosphorylate BTK Show undefined attributes

authored	[InstanceEdit:9606150] May, Bruce, 2018-04-14
catalystActivity	[CatalystActivity:9606885] protein tyrosine kinase activity of LYN, p-SYK [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9606166] May, Bruce, 2018-04-19
dbId	9606163
deleted	[Deleted:9613688] Deletion of instance: 983704
displayName	p-SYK and LYN phosphorylate BTK
edited	[InstanceEdit:9606150] May, Bruce, 2018-04-14
eventOf	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[Reaction:R-HSA-9606159] BTK autophosphorylates - Homo sapiens
inferredFrom	[Reaction:R-GGA-9607039] LYN,SYK phosphorylate BTK - Gallus gallus [Reaction:R-MMU-9607032] Lyn, p-Syk phosphorylate Btk - Mus musculus
input	[Complex:R-HSA-9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1169540] BLNK mediates Syk-dependent Btk activation [LiteratureReference:9606860] Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity [LiteratureReference:9609260] In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies [LiteratureReference:9609258] Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-SYK and LYN phosphorylate BTK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9606149] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9613695] Wienands, J, 2018-07-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9606163
summation	[Summation:9606898] LYN and activated (phosphorylated) SYK phosphorylate BTK (Ba...

Referrals

(replacementInstances)	[Deleted:9613688] Deletion of instance: 983704
(hasEvent)	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[Reaction:R-HSA-9606159] BTK autophosphorylates
(inferredTo)	[Reaction:R-GGA-9607039] LYN,SYK phosphorylate BTK [Reaction:R-MMU-9607032] Lyn, p-Syk phosphorylate Btk