Reactome | BTK [cytosol]

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BTK [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-2197681] Src-kinases [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-8964296] Active Gq:BTK [plasma membrane] - Homo sapiens [Complex:R-HSA-2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] - Homo sapiens [Complex:R-HSA-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76 - Homo sapiens [Reaction:R-HSA-8964280] Active Gq binds BTK - Homo sapiens [Reaction:R-HSA-8964274] G alpha (12) binds BTK - Homo sapiens [Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Homo sapiens [Reaction:R-HSA-2559414] Activated TLR2/4:TIRAP interacts with BTK - Homo sapiens [Reaction:R-HSA-2559414] Activated TLR2/4:TIRAP interacts with BTK - Homo sapiens [Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Homo sapiens
created	[InstanceEdit:197949] de Bono, B, 2007-05-15 17:13:34
dbId	197948
displayName	BTK [cytosol]
endCoordinate	659
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-2685636] Btk [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-197948] BTK [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-197948] BTK [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-197948] BTK [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-197948] BTK [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-197948] BTK [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-197948] BTK [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-197948] BTK [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-197948] BTK [cytosol] - Drosophila melanogaster
maxDepth	1
memberOf	[CandidateSet:R-HSA-2685658] TEC,BTK,ITK,(TXK) [cytosol] - Homo sapiens
name	BTK Tyrosine-protein kinase BTK BTK_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q06187] UniProt:Q06187 BTK
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-197948
startCoordinate	2

Referrals

(hasComponent)	[Complex:R-HSA-2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] [Complex:R-HSA-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] [Complex:R-HSA-8964296] Active Gq:BTK [plasma membrane] [Complex:R-HSA-8964310] G alpha (12):BTK [plasma membrane] [Complex:R-HSA-8964249] PIP3:BTK:G-protein beta-gamma complex [plasma membrane] [Complex:R-HSA-2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] [Complex:R-HSA-2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] [Complex:R-HSA-9606157] BTK:PIP3 [plasma membrane]
(input)	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76 [Reaction:R-HSA-8964280] Active Gq binds BTK [Reaction:R-HSA-8964274] G alpha (12) binds BTK [Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-HSA-2559414] Activated TLR2/4:TIRAP interacts with BTK [Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
(hasMember)	[CandidateSet:R-HSA-2685658] TEC,BTK,ITK,(TXK) [cytosol]
(hasCandidate)	[CandidateSet:R-HSA-2197681] Src-kinases [cytosol]
(activeUnit)	[CatalystActivity:2206268] protein tyrosine kinase activity of TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]

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