Reactome | Activated NTRK3 signals through PI3K

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Activated NTRK3 signals through PI3K Show undefined attributes

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
created	[InstanceEdit:9603391] Orlic-Milacic, Marija, 2018-03-21
crossReference	[DatabaseIdentifier:12819467] BioModels Database:BIOMD0000000581 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940
dbId	9603381
displayName	Activated NTRK3 signals through PI3K
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9034015] Signaling by NTRK3 (TRKC) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9603407] Activated NTRK3 binds PI3K - Homo sapiens [Reaction:R-HSA-9603419] Activated NTRK3 binds SRC - Homo sapiens [Reaction:R-HSA-9603420] Activated NTRK3 promotes SRC autophosphorylation - Homo sapiens [Reaction:R-HSA-9603437] Activated NTRK3 binds IRS1 - Homo sapiens [BlackBoxEvent:R-HSA-9603445] Activated NTRK3 stimulates PI3K activity - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events [LiteratureReference:9603388] c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway [LiteratureReference:9603392] A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation [LiteratureReference:9603393] ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation [LiteratureReference:9603384] The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activated NTRK3 signals through PI3K
orthologousEvent	[Pathway:R-SSC-9603381] Activated NTRK3 signals through PI3K - Sus scrofa [Pathway:R-BTA-9603381] Activated NTRK3 signals through PI3K - Bos taurus [Pathway:R-CFA-9603381] Activated NTRK3 signals through PI3K - Canis familiaris [Pathway:R-RNO-9603381] Activated NTRK3 signals through PI3K - Rattus norvegicus [Pathway:R-MMU-9603381] Activated NTRK3 signals through PI3K - Mus musculus
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9603381
summation	[Summation:9603383] The PI3K complex, composed of PIK3R1 and PIK3CA, co-immunopr...

Referrals

(hasEvent)

[Pathway:R-HSA-9034015] Signaling by NTRK3 (TRKC)

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