Activated NTRK3 stimulates PI3K activity

Stable Identifier
R-HSA-9603445
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Activated NTRK3 stimulates PI3K activity
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Activation of PI3K signaling downstream of NTRK3 (TRKC) is evident from PI3K-dependent activating phosphorylation of AKT in response to NTRK3 activity. SRC and IRS1 contribute to NTRK3-mediated induction of PI3K activity, but the exact mechanism is not known (Tognon et al. 2001, Jin et al. 2008).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane]

Physical Entity
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
This event is regulated
Positively by
Regulator
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC,(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
Inferred From
Activated Ntrk3 stimulates PI3K activity (Mus musculus)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-21)
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