Activated NTRK3 stimulates PI3K activity

Stable Identifier
R-HSA-9603445
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Activation of PI3K signaling downstream of NTRK3 (TRKC) is evident from PI3K-dependent activating phosphorylation of AKT in response to NTRK3 activity. SRC and IRS1 contribute to NTRK3-mediated induction of PI3K activity, but the exact mechanism is not known (Tognon et al. 2001, Jin et al. 2008).

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Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane]
Physical Entity
Activity
This event is regulated
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