Activated NTRK3 stimulates PI3K activity

Stable Identifier
R-HSA-9603445
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Activated NTRK3 stimulates PI3K activity
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Activation of PI3K signaling downstream of NTRK3 (TRKC) is evident from PI3K-dependent activating phosphorylation of AKT in response to NTRK3 activity. SRC and IRS1 contribute to NTRK3-mediated induction of PI3K activity, but the exact mechanism is not known (Tognon et al. 2001, Jin et al. 2008).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane]

Physical Entity
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
This event is regulated
Positively by
Regulator
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC,(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
Inferred From
Activated Ntrk3 stimulates PI3K activity (Mus musculus)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-21)
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