Reactome | Activation of Rap1 by membrane-associated GEFs

Schema > Reaction > Entries

Activation of Rap1 by membrane-associated GEFs Show undefined attributes

catalystActivity	[CatalystActivity:10484803] guanyl-nucleotide exchange factor activity of Rap1 cAMP-GEFs [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10484805
displayName	Activation of Rap1 by membrane-associated GEFs
eventOf	[Pathway:R-SSC-354192] Integrin signaling - Sus scrofa [Pathway:R-SSC-392517] Rap1 signalling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-354060] Translocation of RIAM to plasma membrane - Sus scrofa [Reaction:R-SSC-392513] Rap1 signal termination by Rap1GAPs - Sus scrofa
inferredFrom	[Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-SSC-354074] RAP1:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of Rap1 by membrane-associated GEFs
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-SSC-354126] RAP1:GTP [plasma membrane]
precedingEvent	[Reaction:R-SSC-392834] Activation of EPACs by cAMP - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-939265
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-392517] Rap1 signalling [Pathway:R-SSC-354192] Integrin signaling
(precedingEvent)	[Reaction:R-SSC-392513] Rap1 signal termination by Rap1GAPs [Reaction:R-SSC-354060] Translocation of RIAM to plasma membrane
(inferredTo)	[Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs

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