Reactome | Rap1 sequesters Raf1 to inhibit ERK cascade

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Rap1 sequesters Raf1 to inhibit ERK cascade Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392833] Jupe, S, 2009-03-09 10:40:38
dbId	392835
displayName	Rap1 sequesters Raf1 to inhibit ERK cascade
edited	[InstanceEdit:939810] Jupe, S, 2010-09-01
eventOf	[Pathway:R-HSA-392517] Rap1 signalling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-167205] RAF1 [cytosol] [Complex:R-HSA-354126] RAP1:GTP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:430246] Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1 [LiteratureReference:430244] RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Rap1 sequesters Raf1 to inhibit ERK cascade
orthologousEvent	[Reaction:R-DDI-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Dictyostelium discoideum [Reaction:R-CEL-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Caenorhabditis elegans [Reaction:R-DME-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Drosophila melanogaster [Reaction:R-GGA-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Gallus gallus [Reaction:R-XTR-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Xenopus tropicalis [Reaction:R-DRE-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Danio rerio [Reaction:R-CFA-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Canis familiaris [Reaction:R-RNO-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Rattus norvegicus [Reaction:R-MMU-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Mus musculus
output	[Complex:R-HSA-430243] Rap1-GTP:Raf1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-354173] Activation of Rap1 by cytosolic GEFs - Homo sapiens [Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:939806] Heemskerk, JW, 2010-09-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392835
summation	[Summation:430254] Active Rap1 binds but does not activate Raf-1, preventing Ra...

Referrals

(hasEvent)

[Pathway:R-HSA-392517] Rap1 signalling