Reactome | Activation of Rap1 by membrane-associated GEFs

Schema > Reaction > Entries

Activation of Rap1 by membrane-associated GEFs Show undefined attributes

catalystActivity	[CatalystActivity:10769208] guanyl-nucleotide exchange factor activity of Rap1 cAMP-GEFs [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10769210
displayName	Activation of Rap1 by membrane-associated GEFs
eventOf	[Pathway:R-CEL-354192] Integrin signaling - Caenorhabditis elegans [Pathway:R-CEL-392517] Rap1 signalling - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Caenorhabditis elegans [Reaction:R-CEL-354060] Translocation of RIAM to plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-392513] Rap1 signal termination by Rap1GAPs - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-CEL-354074] RAP1:GDP [plasma membrane]
isInDisease	false
isInferred	true
name	Activation of Rap1 by membrane-associated GEFs
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-CEL-354126] RAP1:GTP [plasma membrane]
precedingEvent	[Reaction:R-CEL-392834] Activation of EPACs by cAMP - Caenorhabditis elegans
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-939265
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-392517] Rap1 signalling [Pathway:R-CEL-354192] Integrin signaling
(precedingEvent)	[Reaction:R-CEL-392835] Rap1 sequesters Raf1 to inhibit ERK cascade [Reaction:R-CEL-392513] Rap1 signal termination by Rap1GAPs [Reaction:R-CEL-354060] Translocation of RIAM to plasma membrane
(inferredTo)	[Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs