Reactome | Signals from agonist receptors (such as GPVI) trigger the pr...

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created	[InstanceEdit:354078] Garapati, P V, 2008-06-16 17:02:05
dbId	354094
displayName	Signals from agonist receptors (such as GPVI) trigger the pr...
literatureReference	[LiteratureReference:215835] Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C [LiteratureReference:354121] CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
modified	[InstanceEdit:392506] Jupe, S, 2009-03-05 11:05:42
schemaClass	Summation
text	Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.

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