Reactome | Phosphorylated TAK1 leaves activated TLR receptor complex

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Phosphorylated TAK1 leaves activated TLR receptor complex Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10146216
displayName	Phosphorylated TAK1 leaves activated TLR receptor complex
eventOf	[Pathway:R-RNO-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Homo sapiens
input	[Complex:R-RNO-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated TAK1 leaves activated TLR receptor complex
output	[Complex:R-RNO-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] [Complex:R-RNO-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-RNO-936951] Activation of TAK1 complex bound to activated TLR4 complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-937075
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(inferredTo)	[Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex

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