Reactome | Phosphorylated TAK1 leaves activated TLR receptor complex

Phosphorylated TAK1 leaves activated TLR receptor complex

Stable Identifier

R-HSA-937075

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
        
        Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Phosphorylated TAK1 leaves activated TLR receptor complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leaves the activated TLR4 complex and translocates to the cytosol

Literature References

PubMed ID	Title	Journal	Year
12242293	Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol Jiang, Z, Ninomiya-Tsuji, J, Qian, Y, Matsumoto, K, Li, X	Mol Cell Biol	2002
12609980	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z, Zamanian-Daryoush, M, Nie, H, Silva, AM, Williams, BR, Li, X	J Biol Chem	2003