Reactome | Phosphorylated TAK1 leaves activated TLR receptor complex

Phosphorylated TAK1 leaves activated TLR receptor complex

Stable Identifier

R-HSA-937075

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
        
        Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)

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Phosphorylated TAK1 leaves activated TLR receptor complex

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Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leaves the activated TLR4 complex and translocates to the cytosol

Literature References

PubMed ID	Title	Journal	Year
12609980	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z, Zamanian-Daryoush, M, Nie, H, Silva, AM, Williams, BR, Li, X	J Biol Chem	2003
12242293	Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol Jiang, Z, Ninomiya-Tsuji, J, Qian, Y, Matsumoto, K, Li, X	Mol Cell Biol	2002