Reactome | Activation of TAK1 complex bound to activated TLR4 complex

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Activation of TAK1 complex bound to activated TLR4 complex Show undefined attributes

catalystActivity	[CatalystActivity:10262474] protein serine/threonine kinase activity of activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10262476
displayName	Activation of TAK1 complex bound to activated TLR4 complex
eventOf	[Pathway:R-CFA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Canis familiaris [Reaction:R-CFA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Canis familiaris [Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Canis familiaris
inferredFrom	[Reaction:R-HSA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Homo sapiens
input	[Complex:R-CFA-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] 4 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of TAK1 complex bound to activated TLR4 complex
output	[Complex:R-CFA-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] 4 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-CFA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-936951
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(precedingEvent)	[Reaction:R-CFA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex [Reaction:R-CFA-450346] activated human TAK1 phosphorylates MKK3/MKK6 [Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7
(inferredTo)	[Reaction:R-HSA-936951] Activation of TAK1 complex bound to activated TLR4 complex