Reactome | Activated TAK1 phosphorylates MKK4/MKK7

Schema > Reaction > Entries

Activated TAK1 phosphorylates MKK4/MKK7 Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:177696] protein serine/threonine kinase activity of Activated TAK complexes [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450337
displayName	Activated TAK1 phosphorylates MKK4/MKK7
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens
followingEvent	[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-450305] MAP2K7,MAP2K4 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:438028] Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction [LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Activated TAK1 phosphorylates MKK4/MKK7
orthologousEvent	[Reaction:R-GGA-437999] Phosphorylation of MKK4 by activated TAK1 - Gallus gallus [Reaction:R-DDI-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Dictyostelium discoideum [Reaction:R-DME-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Drosophila melanogaster [Reaction:R-GGA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Gallus gallus [Reaction:R-XTR-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Xenopus tropicalis [Reaction:R-DRE-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Danio rerio [Reaction:R-SSC-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Sus scrofa [Reaction:R-BTA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Bos taurus [Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Canis familiaris [Reaction:R-RNO-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Rattus norvegicus [Reaction:R-MMU-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-450299] p-MAP2K4/p-MAP2K7 [cytosol]
precedingEvent	[Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex - Homo sapiens [Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Homo sapiens [Reaction:R-HSA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450337
summation	[Summation:450330] In human, phosphorylation of MKK4 (MAP2K4) and MKK7 (MAP2K7)...
updateTrackers	[UpdateTracker:9790071] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v35:[modifyText] [UpdateTracker:9788138] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v43:[modifyText] [UpdateTracker:9779901] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v64:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790071] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v35:[modifyText] [UpdateTracker:9788138] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v43:[modifyText] [UpdateTracker:9779901] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v64:[modifyText]
(hasEvent)	[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
(precedingEvent)	[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7

Cite Us!