Reactome | PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

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PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Show undefined attributes

authored	[InstanceEdit:888605] Mahajan, SS, 2010-06-29
catalystActivity	[CatalystActivity:916852] 4-aminobutyrate:2-oxoglutarate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:916854] Mahajan, SS, 2010-07-29
crossReference	[DatabaseIdentifier:12667614] RHEA:23353
dbId	916855
displayName	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
edited	[InstanceEdit:918271] Mahajan, SS, 2010-08-03
eventOf	[Pathway:R-HSA-916853] Degradation of GABA - Homo sapiens
followingEvent	[Reaction:R-HSA-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate - Homo sapiens [Reaction:R-HSA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-916850] GABA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:916843] Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Conversion of GABA to Succinate Semialdehyde
orthologousEvent	[Reaction:R-DRE-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Danio rerio [Reaction:R-SCE-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Saccharomyces cerevisiae [Reaction:R-SPO-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Schizosaccharomyces pombe [Reaction:R-DDI-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Dictyostelium discoideum [Reaction:R-CEL-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Caenorhabditis elegans [Reaction:R-DME-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Drosophila melanogaster [Reaction:R-GGA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Gallus gallus [Reaction:R-XTR-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Xenopus tropicalis [Reaction:R-SSC-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Sus scrofa [Reaction:R-BTA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Bos taurus [Reaction:R-CFA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Canis familiaris [Reaction:R-RNO-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Rattus norvegicus [Reaction:R-MMU-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Mus musculus
output	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-880046] SUCCSA [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-9653180] GABA translocates from cytosol to mitochondrial matrix - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49 [InstanceEdit:9653791] Jassal, Bijay, 2019-07-15
revised	[InstanceEdit:9653175] D'Eustachio, Peter, 2019-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-916855
summation	[Summation:917746] GABA and 2-oxoglutarate (2OG) are converted to succinate sem...
updateTrackers	[UpdateTracker:9777804] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v69:[removeInput, removeOutput] [UpdateTracker:9777627] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v70:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777804] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v69:[removeInput, removeOutput] [UpdateTracker:9777627] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v70:[modifyText]
(hasEvent)	[Pathway:R-HSA-916853] Degradation of GABA
(precedingEvent)	[Reaction:R-HSA-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate [Reaction:R-HSA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA

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