Reactome | PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

Schema > Reaction > Entries

PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Show undefined attributes

catalystActivity	[CatalystActivity:10145511] 4-aminobutyrate:2-oxoglutarate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10145513
displayName	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
eventOf	[Pathway:R-RNO-916853] Degradation of GABA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate - Rattus norvegicus [Reaction:R-RNO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-916850] GABA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Conversion of GABA to Succinate Semialdehyde
output	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-880046] SUCCSA [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-916855
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-916853] Degradation of GABA
(precedingEvent)	[Reaction:R-RNO-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate [Reaction:R-RNO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA
(inferredTo)	[Reaction:R-HSA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

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