Reactome | PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

Schema > Reaction > Entries

PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Show undefined attributes

catalystActivity	[CatalystActivity:10684411] 4-aminobutyrate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10684413
displayName	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
eventOf	[Pathway:R-DME-916853] Degradation of GABA - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate - Drosophila melanogaster [Reaction:R-DME-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-916850] GABA [mitochondrial matrix]
isInDisease	false
isInferred	true
name	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Conversion of GABA to Succinate Semialdehyde
output	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-880046] SUCCSA [mitochondrial matrix]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-916855
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate [Reaction:R-DME-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA
(hasEvent)	[Pathway:R-DME-916853] Degradation of GABA
(inferredTo)	[Reaction:R-HSA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA