PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

Stable Identifier
R-HSA-916855
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Conversion of GABA to Succinate Semialdehyde
ReviewStatus
5/5
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PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
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GABA and 2-oxoglutarate (2OG) are converted to succinate semialdehyde (SUCCSA) and L-glutamate (L-Glu) by 4 aminobutyrate aminotransferase (ABAT). The reaction takes place in the mitochondrial matrix. The active form of the enzyme is a dimer, with each subunit associated with a molecule of pyridoxal phosphate (PXLP) (De Biase et al. 1995).
Literature References
PubMed ID Title Journal Year
7851425 Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase

Bossa, F, Barra, D, Simmaco, M, John, RA, De Biase, D

Eur J Biochem 1995
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Catalyst Activity

4-aminobutyrate:2-oxoglutarate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]

Physical Entity
PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix] (Homo sapiens)
Activity
4-aminobutyrate:2-oxoglutarate transaminase activity (GO:0034386)
Orthologous Events
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2010-06-30)
Reviewed
Jassal, B  (2019-07-15)
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-07-29)
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