Reactome | GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

Stable Identifier

R-HSA-914012

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

Synonyms

Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein

ReviewStatus

5/5

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GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

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The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltransferase which mediates core 2 O-glycan branching by the addition of N-acetylgalactosamine, an important step in mucin-type biosynthesis. There are 3 defined members in humans, 1, 3 and 4 (Bierhuizen and Fukuda, 1992; Yeh et al, 1999; Schwientek et al, 2000). Two members (6 and 7) may be part of the family based on sequence similarity.

Literature References

PubMed ID	Title	Journal	Year
9915862	Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches Fukuda, M, Yeh, JC, Ong, E	J Biol Chem	1999
1329093	Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen Fukuda, M, Bierhuizen, MF	Proc Natl Acad Sci U S A	1992
10753916	Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 beta1, 6-n-acetylglucosaminyltransferase Fukuda, M, Yeh, JC, van Kessel, AG, Schwientek, T, Merkx, G, Levery, SB, Keck, B, Clausen, H	J Biol Chem	2000