Reactome | GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

Schema > Reaction > Entries

GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins Show undefined attributes

catalystActivity	[CatalystActivity:10678306] beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity of GCNTs [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10678308
displayName	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
eventOf	[Pathway:R-XTR-913709] O-linked glycosylation of mucins - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins - Xenopus tropicalis [Reaction:R-XTR-5694487] A4GNT transfers GlcNAc to core 2 mucins - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Homo sapiens
input	[DefinedSet:R-XTR-1462240] Core 1 mucins [Golgi lumen] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
output	[DefinedSet:R-XTR-1462066] Core 2 mucins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-XTR-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-914012
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-913709] O-linked glycosylation of mucins
(precedingEvent)	[Reaction:R-XTR-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins [Reaction:R-XTR-5694487] A4GNT transfers GlcNAc to core 2 mucins
(inferredTo)	[Reaction:R-HSA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

Cite Us!