Reactome | GALNTs transfer GalNAc to Mucins to form Tn antigens

GALNTs transfer GalNAc to Mucins to form Tn antigens

Stable Identifier

R-HSA-913675

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

Addition of GalNAc to mucins to form the Tn antigen

ReviewStatus

5/5

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GALNTs transfer GalNAc to Mucins to form Tn antigens

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The family of UDP GalNAc:polypeptide N acetylgalactosaminyltransferases (GalNAc transferases, GALNTs) carry out the addition of N acetylgalactosamine on serine, threonine or possibly tyrosine residues on a wide variety of proteins, and most commonly associated with mucins (Wandall et al. 1997). This reaction takes place in the Golgi apparatus (Rottger et al. 1998). There are 20 known members of the GALNT family, 15 of which have been characterised and 5 candidate members which are thought to belong to this family based on sequence similarity (Bennett et al. 2012). The GALNT-family is classified as belonging to CAZy family GT27. The Tn antigen is the simplest possible amino acid–carbohydrate glycoconjugate and comprises a GalNAc α-O-linked to either serine or threonine. In normal mammalian mucins, GalNAc is substituted by Gal, GlcNAc, or GalNAc forming up to eight different core structures. The unsubstituted Tn antigen is often found in cancer and is associated with poor prognosis (Kamerling 2007).

Literature References

PubMed ID	Title	Journal	Year
22183981	Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family Fritz, TA, Mandel, U, Bennett, EP, Tabak, LA, Gerken, TA, Clausen, H	Glycobiology	2012
9394011	Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus Whitehouse, C, White, J, Bennett, EP, Olivo, JC, Röttger, S, Berger, EG, Nilsson, T, Stark, A, Wandall, HH, Clausen, H	J Cell Sci	1998
9295285	Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3 Burchell, J, Bennett, EP, Hassan, H, Taylor-Papadimitriou, J, Roepstorff, P, Hollingsworth, MA, Kristensen, AK, Nielsen, PA, Mirgorodskaya, E, Wandall, HH, Clausen, H	J Biol Chem	1997