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Entries
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
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authored
[InstanceEdit:977066] Jassal, B, 2010-10-15
catalystActivity
[CatalystActivity:977229] beta-galactoside alpha-2,6-sialyltransferase activity of ST6GAL1 [Golgi membrane]
category
transition
compartment
[Compartment:17963] Golgi lumen
[Compartment:20699] Golgi membrane
created
[InstanceEdit:977066] Jassal, B, 2010-10-15
dbId
977071
displayName
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
edited
[InstanceEdit:977066] Jassal, B, 2010-10-15
eventOf
[Pathway:R-HSA-977068] Termination of O-glycan biosynthesis - Homo sapiens
input
[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen]
[DefinedSet:R-HSA-913659] Tn antigens [Golgi lumen]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:977064] The B cell antigen CD75 is a cell surface sialytransferase
[LiteratureReference:9756056] Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen
[LiteratureReference:9756071] The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
orthologousEvent
[Reaction:R-DME-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Drosophila melanogaster
[Reaction:R-GGA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Gallus gallus
[Reaction:R-XTR-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Xenopus tropicalis
[Reaction:R-DRE-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Danio rerio
[Reaction:R-SSC-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Sus scrofa
[Reaction:R-BTA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Bos taurus
[Reaction:R-CFA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Canis familiaris
[Reaction:R-RNO-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Rattus norvegicus
[Reaction:R-MMU-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Mus musculus
output
[SimpleEntity:R-ALL-727810] CMP [Golgi lumen]
[SimpleEntity:R-ALL-425969] H+ [Golgi lumen]
[DefinedSet:R-HSA-1463504] Sialyl Tn antigens [Golgi lumen]
precedingEvent
[Reaction:R-HSA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1964508] Ferrer, A, 2011-11-04
[InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-977071
summation
[Summation:977074] Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) tra...
updateTrackers
[UpdateTracker:9953676] Update Tracker - [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - v93:[removeOutput]
[UpdateTracker:9775488] Update Tracker - [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - v79:[addLiteratureReference, modifyText]
[UpdateTracker:9786959] Update Tracker - [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - v46:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9953676] Update Tracker - [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - v93:[removeOutput]
[UpdateTracker:9775488] Update Tracker - [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - v79:[addLiteratureReference, modifyText]
[UpdateTracker:9786959] Update Tracker - [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - v46:[modifyText]
(hasEvent)
[Pathway:R-HSA-977068] Termination of O-glycan biosynthesis
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