Reactome | Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

Schema > BlackBoxEvent > Entries

Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG Show undefined attributes

authored	[InstanceEdit:9038168] Rothfels, Karen, 2018-02-23
catalystActivity	[CatalystActivity:9038128] ATP hydrolysis activity of HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9038160] Rothfels, Karen, 2018-02-23
dbId	9038161
displayName	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
edited	[InstanceEdit:9038276] Rothfels, Karen, 2018-02-23
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9038163] ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators - Homo sapiens
input	[Complex:R-HSA-1254381] ESR1 dimer:ESTG [nucleoplasm] [Complex:R-HSA-9038123] HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9038143] Progesterone receptor modulates ER? action in breast cancer [LiteratureReference:9038149] Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cells [LiteratureReference:8937263] Breast cancer, estrogen receptor and ligands
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
orthologousEvent	[BlackBoxEvent:R-DME-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Drosophila melanogaster [BlackBoxEvent:R-GGA-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Gallus gallus [BlackBoxEvent:R-DRE-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Danio rerio [BlackBoxEvent:R-SSC-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Sus scrofa [BlackBoxEvent:R-BTA-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Bos taurus [BlackBoxEvent:R-RNO-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Rattus norvegicus [BlackBoxEvent:R-MMU-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-9038156] ESR1:ER:PGR:P4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5324621] FKBP4 [nucleoplasm] [DefinedSet:R-HSA-5082395] HSP90:HSP90 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-5082403] PTGES3 [nucleoplasm]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9038161
summation	[Summation:9038158] In addition to being a target of estrogen-dependent transcri...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9038163] ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators
(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression