Reactome | Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

Schema > BlackBoxEvent > Entries

Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG Show undefined attributes

catalystActivity	[CatalystActivity:10431753] ATP hydrolysis activity of HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10431755
displayName	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
eventOf	[Pathway:R-BTA-9018519] Estrogen-dependent gene expression - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-9038163] ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG - Homo sapiens
input	[Complex:R-BTA-1254381] ESR1 dimer:ESTG [nucleoplasm] [Complex:R-BTA-9038123] HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-BTA-9038156] ESR1:ER:PGR:P4 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5324621] FKBP4 [nucleoplasm] [DefinedSet:R-BTA-5082395] HSP90:HSP90 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-BTA-5082403] PTGES3 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-9038161
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[BlackBoxEvent:R-BTA-9038163] ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators
(inferredTo)	[BlackBoxEvent:R-HSA-9038161] Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

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