Reactome | NTRK3 dimers trans-autophosphorylate

Schema > Reaction > Entries

NTRK3 dimers trans-autophosphorylate Show undefined attributes

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
catalystActivity	[CatalystActivity:9034733] protein tyrosine kinase activity of NTF3:NTRK3 homodimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9034719] Orlic-Milacic, Marija, 2018-01-10
dbId	9034714
displayName	NTRK3 dimers trans-autophosphorylate
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9034013] NTF3 activates NTRK3 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9034862] Activated NTRK3 binds SHC1 - Homo sapiens [Reaction:R-HSA-9603437] Activated NTRK3 binds IRS1 - Homo sapiens [Reaction:R-HSA-9603419] Activated NTRK3 binds SRC - Homo sapiens [Reaction:R-HSA-9603407] Activated NTRK3 binds PI3K - Homo sapiens [Reaction:R-HSA-9034796] Activated NTRK3 binds PLCG1 - Homo sapiens [BlackBoxEvent:R-HSA-9603719] Protein tyrosine phosphatases dephosphorylate NTRK3 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172228] positive regulation of neurotrophin TRK receptor signaling pathway
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9034025] NTF3:NTRK3 homodimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9034729] Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease [LiteratureReference:9034747] An immunoglobulin-like domain determines the specificity of neurotrophin receptors [LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events [LiteratureReference:9608130] Neurotrophins: roles in neuronal development and function
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	NTRK3 dimers trans-autophosphorylate
negativePrecedingEvent	[NegativePrecedingEvent:9865794] Negative relationship: Protein tyrosine phosphatases dephosphorylate NTRK3
orthologousEvent	[Reaction:R-SSC-9034714] NTRK3 dimers trans-autophosphorylate - Sus scrofa [Reaction:R-BTA-9034714] NTRK3 dimers trans-autophosphorylate - Bos taurus [Reaction:R-CFA-9034714] NTRK3 dimers trans-autophosphorylate - Canis familiaris [Reaction:R-RNO-9034714] NTRK3 dimers trans-autophosphorylate - Rattus norvegicus [Reaction:R-MMU-9034714] NTRK3 dimers trans-autophosphorylate - Mus musculus
output	10 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9034727] NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-9034016] NTF3 binds NTRK3 - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9034714
summation	[Summation:9034739] NTRK3 (TRKC), activated by NTF3 binding, trans-autophosphory...

Referrals

(precedingEvent)	[Reaction:R-HSA-9034862] Activated NTRK3 binds SHC1 [Reaction:R-HSA-9603437] Activated NTRK3 binds IRS1 [Reaction:R-HSA-9603419] Activated NTRK3 binds SRC [Reaction:R-HSA-9603407] Activated NTRK3 binds PI3K [Reaction:R-HSA-9034796] Activated NTRK3 binds PLCG1 [BlackBoxEvent:R-HSA-9603719] Protein tyrosine phosphatases dephosphorylate NTRK3
(hasEvent)	[Pathway:R-HSA-9034013] NTF3 activates NTRK3 signaling