NTRK3 (TRKC), activated by NTF3 binding, trans-autophosphorylates on tyrosine residues in the intracellular domain (Urfer et al. 1995, Yuen and Mobley 1999, Huang and Reichardt 2001). Tyrosine residue Y516 of NTRK3 was directly shown to be autophosphorylated (Werner et al. 2014), while tyrosine residues Y705, Y709, Y710 and Y834 are predicted to be phosphorylated based on sequence similarity with NTRK2 (TRKB).
Urfer, R, Parada, LF, Shelton, DL, O'Connell, L, Presta, LG, Tsoulfas, P
Yuen, EC, Mobley, WC
Reichardt, LF, Huang, EJ
Iyer, R, Goldmuntz, E, Simpson, AM, Brodeur, GM, Latney, B, Werner, P, Paluru, P
protein tyrosine kinase activity of NTF3:NTRK3 homodimer [plasma membrane]
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