NTRK3 dimers trans-autophosphorylate

Stable Identifier
R-HSA-9034714
Type
Reaction
Species
Homo sapiens
Compartment
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NTRK3 (TRKC), activated by NTF3 binding, trans-autophosphorylates on tyrosine residues in the intracellular domain (Urfer et al. 1995, Yuen and Mobley 1999, Huang and Reichardt 2001). Tyrosine residue Y516 of NTRK3 was directly shown to be autophosphorylated (Werner et al. 2014), while tyrosine residues Y705, Y709, Y710 and Y834 are predicted to be phosphorylated based on sequence similarity with NTRK2 (TRKB).

Literature References
PubMed ID Title Journal Year
7796806 An immunoglobulin-like domain determines the specificity of neurotrophin receptors

Urfer, R, Parada, LF, Shelton, DL, O'Connell, L, Presta, LG, Tsoulfas, P

EMBO J. 1995
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
11520916 Neurotrophins: roles in neuronal development and function

Reichardt, LF, Huang, EJ

Annu. Rev. Neurosci. 2001
25196463 Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease

Iyer, R, Goldmuntz, E, Simpson, AM, Brodeur, GM, Latney, B, Werner, P, Paluru, P

Hum. Mutat. 2014
Participants
Participates
Event Information
Catalyst Activity

protein tyrosine kinase activity of NTF3:NTRK3 homodimer [plasma membrane]

Orthologous Events
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