NTRK3 dimers trans-autophosphorylate

Stable Identifier
R-HSA-9034714
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NTRK3 (TRKC), activated by NTF3 binding, trans-autophosphorylates on tyrosine residues in the intracellular domain (Urfer et al. 1995, Yuen and Mobley 1999, Huang and Reichardt 2001). Tyrosine residue Y516 of NTRK3 was directly shown to be autophosphorylated (Werner et al. 2014), while tyrosine residues Y705, Y709, Y710 and Y834 are predicted to be phosphorylated based on sequence similarity with NTRK2 (TRKB).

Literature References
PubMed ID Title Journal Year
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
7796806 An immunoglobulin-like domain determines the specificity of neurotrophin receptors

Urfer, R, Tsoulfas, P, O'Connell, L, Shelton, DL, Parada, LF, Presta, LG

EMBO J. 1995
11520916 Neurotrophins: roles in neuronal development and function

Huang, EJ, Reichardt, LF

Annu. Rev. Neurosci. 2001
25196463 Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease

Werner, P, Paluru, P, Simpson, AM, Latney, B, Iyer, R, Brodeur, GM, Goldmuntz, E

Hum. Mutat. 2014
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of NTF3:NTRK3 homodimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created