Reactome | NTRK3 dimers trans-autophosphorylate

NTRK3 dimers trans-autophosphorylate

Stable Identifier

R-HSA-9034714

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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NTRK3 (TRKC), activated by NTF3 binding, trans-autophosphorylates on tyrosine residues in the intracellular domain (Urfer et al. 1995, Yuen and Mobley 1999, Huang and Reichardt 2001). Tyrosine residue Y516 of NTRK3 was directly shown to be autophosphorylated (Werner et al. 2014), while tyrosine residues Y705, Y709, Y710 and Y834 are predicted to be phosphorylated based on sequence similarity with NTRK2 (TRKB).

Literature References

PubMed ID	Title	Journal	Year
7796806	An immunoglobulin-like domain determines the specificity of neurotrophin receptors Urfer, R, Parada, LF, Shelton, DL, O'Connell, L, Presta, LG, Tsoulfas, P	EMBO J.	1995
10486198	Early BDNF, NT-3, and NT-4 signaling events Yuen, EC, Mobley, WC	Exp. Neurol.	1999
11520916	Neurotrophins: roles in neuronal development and function Reichardt, LF, Huang, EJ	Annu. Rev. Neurosci.	2001
25196463	Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease Iyer, R, Goldmuntz, E, Simpson, AM, Brodeur, GM, Latney, B, Werner, P, Paluru, P	Hum. Mutat.	2014