Reactome | NTF3 activates NTRK3 signaling

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NTF3 activates NTRK3 signaling Show undefined attributes

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
created	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
dbId	9034013
displayName	NTF3 activates NTRK3 signaling
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9034015] Signaling by NTRK3 (TRKC) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172228] positive regulation of neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9034016] NTF3 binds NTRK3 - Homo sapiens [Reaction:R-HSA-9034714] NTRK3 dimers trans-autophosphorylate - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9034095] trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3 [LiteratureReference:9034667] Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors [LiteratureReference:9034729] Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease [LiteratureReference:9608130] Neurotrophins: roles in neuronal development and function [LiteratureReference:9608125] TrkC isoforms with inserts in the kinase domain show impaired signaling responses
maxDepth	2
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	NTF3 activates NTRK3 signaling
orthologousEvent	[Pathway:R-SSC-9034013] NTF3 activates NTRK3 signaling - Sus scrofa [Pathway:R-BTA-9034013] NTF3 activates NTRK3 signaling - Bos taurus [Pathway:R-CFA-9034013] NTF3 activates NTRK3 signaling - Canis familiaris [Pathway:R-RNO-9034013] NTF3 activates NTRK3 signaling - Rattus norvegicus [Pathway:R-MMU-9034013] NTF3 activates NTRK3 signaling - Mus musculus
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9034013
summation	[Summation:9603876] NTRK3 (TRKC) is activated by binding to its ligand neurotrop...

Referrals

(hasEvent)

[Pathway:R-HSA-9034015] Signaling by NTRK3 (TRKC)