Reactome | Interleukin-27 signaling

Schema > Pathway > Entries

Interleukin-27 signaling Show undefined attributes

authored	[InstanceEdit:8950026] Duenas, Corina, 2016-12-02 [InstanceEdit:448382] Jupe, S, 2009-11-24
created	[InstanceEdit:9020957] Jupe, Steve, 2017-09-12
dbId	9020956
displayName	Interleukin-27 signaling
edited	[InstanceEdit:9028725] Jupe, Steve, 2017-11-09
eventOf	[Pathway:R-HSA-447115] Interleukin-12 family signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:383623] interleukin-27-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8950387] CANX binds EBI3 - Homo sapiens [BlackBoxEvent:R-HSA-8950342] EBI3:CANX binds IL27 - Homo sapiens [BlackBoxEvent:R-HSA-8950398] CANX dissociates from IL27:EBI3 - Homo sapiens [BlackBoxEvent:R-HSA-448421] Interleukin-27 translocates from the ER lumen to the extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-8950271] sIL27RA translocates from the cytoplasm to the extracellular region - Homo sapiens [Reaction:R-HSA-8950766] IL27RA dimerizes - Homo sapiens [Reaction:R-HSA-8950716] IL27RA binds JAK1 - Homo sapiens [Reaction:R-HSA-1067646] JAK1,JAK2,(TYK2) bind IL6ST - Homo sapiens [Reaction:R-HSA-448427] Interleukin-27 binds Interleukin-27 receptor - Homo sapiens [Reaction:R-HSA-8950210] Interleukin-27 dissociates from Interleukin-27 receptor - Homo sapiens [BlackBoxEvent:R-HSA-8950537] JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated - Homo sapiens [BlackBoxEvent:R-HSA-8950340] IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-8950518] STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex - Homo sapiens [BlackBoxEvent:R-HSA-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Homo sapiens [BlackBoxEvent:R-HSA-8950441] p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor - Homo sapiens [Reaction:R-HSA-8950782] p-STAT1 binds p-STAT3 - Homo sapiens [BlackBoxEvent:R-HSA-8950733] p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-8950504] IL27 binds CRLF1 - Homo sapiens [BlackBoxEvent:R-HSA-8950731] CRLF1:IL27 translocates to the extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-8950674] IL27 translocates from the cytosol to the extracellular space - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:9028742] The immunobiology of interleukin-27
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interleukin-27 signaling
orthologousEvent	[Pathway:R-DDI-9020956] Interleukin-27 signaling - Dictyostelium discoideum [Pathway:R-CEL-9020956] Interleukin-27 signaling - Caenorhabditis elegans [Pathway:R-DME-9020956] Interleukin-27 signaling - Drosophila melanogaster [Pathway:R-GGA-9020956] Interleukin-27 signaling - Gallus gallus [Pathway:R-XTR-9020956] Interleukin-27 signaling - Xenopus tropicalis [Pathway:R-SSC-9020956] Interleukin-27 signaling - Sus scrofa [Pathway:R-BTA-9020956] Interleukin-27 signaling - Bos taurus [Pathway:R-CFA-9020956] Interleukin-27 signaling - Canis familiaris [Pathway:R-RNO-9020956] Interleukin-27 signaling - Rattus norvegicus [Pathway:R-MMU-9020956] Interleukin-27 signaling - Mus musculus
releaseDate	2017-12-13
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12 [InstanceEdit:6809153] Narazaki, M, Tanaka, M, 2015-11-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9020956
summation	[Summation:9028746] Interleukin-27 (IL27) is a heterodimeric cytokine that conta...
updateTrackers	[UpdateTracker:9775830] Update Tracker - [Pathway:9020956] Interleukin-27 signaling - v78:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775830] Update Tracker - [Pathway:9020956] Interleukin-27 signaling - v78:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-447115] Interleukin-12 family signaling

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