Reactome | Interleukin-12 family signaling

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Interleukin-12 family signaling Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
dbId	447115
displayName	Interleukin-12 family signaling
doi	10.3180/R-HSA-447115.3
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
eventOf	[Pathway:R-HSA-449147] Signaling by Interleukins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1301067] interleukin-12-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9020591] Interleukin-12 signaling - Homo sapiens [Pathway:R-HSA-9020933] Interleukin-23 signaling - Homo sapiens [Pathway:R-HSA-9020956] Interleukin-27 signaling - Homo sapiens [Pathway:R-HSA-8984722] Interleukin-35 Signalling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:447147] Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells [LiteratureReference:8950399] Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease [LiteratureReference:8950180] IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling Pathways
maxDepth	4
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interleukin-12 family signaling
orthologousEvent	[Pathway:R-DDI-447115] Interleukin-12 family signaling - Dictyostelium discoideum [Pathway:R-CEL-447115] Interleukin-12 family signaling - Caenorhabditis elegans [Pathway:R-DME-447115] Interleukin-12 family signaling - Drosophila melanogaster [Pathway:R-GGA-447115] Interleukin-12 family signaling - Gallus gallus [Pathway:R-XTR-447115] Interleukin-12 family signaling - Xenopus tropicalis [Pathway:R-DRE-447115] Interleukin-12 family signaling - Danio rerio [Pathway:R-SSC-447115] Interleukin-12 family signaling - Sus scrofa [Pathway:R-BTA-447115] Interleukin-12 family signaling - Bos taurus [Pathway:R-CFA-447115] Interleukin-12 family signaling - Canis familiaris [Pathway:R-RNO-447115] Interleukin-12 family signaling - Rattus norvegicus [Pathway:R-MMU-447115] Interleukin-12 family signaling - Mus musculus
releaseDate	2016-03-23
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-447115
summation	[Summation:447238] Interleukin-12 (IL-12) is a heterodimer of interleukin-12 su...
updateTrackers	[UpdateTracker:9778789] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v67:[updateContainedPathway] [UpdateTracker:9775520] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v78:[updateIndirectRLE] [UpdateTracker:9780389] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v63:[add_removeHasEvent, updateIndirectRLE] [UpdateTracker:9780581] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v62:[removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9779776] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v64:[updateIndirectRLE] [UpdateTracker:9781617] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v60:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9780921] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v61:[add_removeHasEvent, modifyText, updateContainedRLE]

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[Pathway:R-HSA-449147] Signaling by Interleukins

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