Reactome | Interleukin-27 signaling

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Interleukin-27 signaling Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10731198
displayName	Interleukin-27 signaling
eventOf	[Pathway:R-XTR-447115] Interleukin-12 family signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383623] interleukin-27-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-8950387] CANX binds EBI3 - Xenopus tropicalis [Reaction:R-XTR-8950766] IL27RA dimerizes - Xenopus tropicalis [BlackBoxEvent:R-XTR-8950537] JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated - Xenopus tropicalis [BlackBoxEvent:R-XTR-8950340] IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation - Xenopus tropicalis [BlackBoxEvent:R-XTR-8950518] STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex - Xenopus tropicalis [BlackBoxEvent:R-XTR-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Xenopus tropicalis [BlackBoxEvent:R-XTR-8950441] p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor - Xenopus tropicalis [Reaction:R-XTR-8950782] p-STAT1 binds p-STAT3 - Xenopus tropicalis [BlackBoxEvent:R-XTR-8950733] p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-9020956] Interleukin-27 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-27 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9020956
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-447115] Interleukin-12 family signaling
(inferredTo)	[Pathway:R-HSA-9020956] Interleukin-27 signaling

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