Reactome | STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction

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STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction Show undefined attributes

authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
catalystActivity	[CatalystActivity:8950237] transmembrane receptor protein tyrosine kinase activity of IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
dbId	8950485
displayName	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
edited	[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
eventOf	[Pathway:R-HSA-9020956] Interleukin-27 signaling - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8950267] IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8981082] IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells [LiteratureReference:8950097] IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes [LiteratureReference:8950745] STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
orthologousEvent	[BlackBoxEvent:R-XTR-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Xenopus tropicalis [BlackBoxEvent:R-SSC-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Sus scrofa [BlackBoxEvent:R-BTA-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Bos taurus [BlackBoxEvent:R-CFA-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Canis familiaris [BlackBoxEvent:R-RNO-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Rattus norvegicus [BlackBoxEvent:R-MMU-8950485] STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8952746] p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8950485
summation	[Summation:8950585] Signal transducer and activator of transcription 3 (STAT3) a...

Referrals

(hasEvent)

[Pathway:R-HSA-9020956] Interleukin-27 signaling