Reactome | JAK1,JAK2,(TYK2) bind IL6ST

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JAK1,JAK2,(TYK2) bind IL6ST Show undefined attributes

authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1067679] Jupe, S, 2010-11-26
dbId	1067646
displayName	JAK1,JAK2,(TYK2) bind IL6ST
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
eventOf	[Pathway:R-HSA-1059683] Interleukin-6 signaling - Homo sapiens [Pathway:R-HSA-9020956] Interleukin-27 signaling - Homo sapiens [Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor - Homo sapiens [Reaction:R-HSA-6783530] gp130:JAKs bind CNTFR - Homo sapiens [BlackBoxEvent:R-HSA-8983518] IL35 binds IL6ST:IL6ST receptor - Homo sapiens [Reaction:R-HSA-1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) - Homo sapiens [Reaction:R-HSA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Homo sapiens
inferredFrom	[Reaction:R-NUL-1067645] Jaks associate with IL6RB (gp130) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-448453] IL6ST [plasma membrane] [CandidateSet:R-HSA-1067656] JAK1, JAK2, (TYK2) [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	JAK1,JAK2,(TYK2) bind IL6ST JAKs associate with IL6ST (gp130)
output	[Complex:R-HSA-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
releaseDate	2011-03-15
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11 [InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1067646
summation	[Summation:1067639] The tyrosine kinases JAK1, JAK2 and Tyk2 associate with the ...
updateTrackers	[UpdateTracker:9788035] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v44:[add_removeInput] [UpdateTracker:9781874] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v60:[modifyText] [UpdateTracker:9984577] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788035] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v44:[add_removeInput] [UpdateTracker:9781874] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v60:[modifyText] [UpdateTracker:9984577] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v96:[modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-8983518] IL35 binds IL6ST:IL6ST receptor [BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor [Reaction:R-HSA-6783530] gp130:JAKs bind CNTFR [Reaction:R-HSA-1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) [Reaction:R-HSA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
(hasEvent)	[Pathway:R-HSA-9020956] Interleukin-27 signaling [Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-HSA-1059683] Interleukin-6 signaling
(inferredTo)	[Reaction:R-NUL-1067645] Jaks associate with IL6RB (gp130)