Reactome | Interleukin-12 signaling

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Interleukin-12 signaling Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04 [InstanceEdit:9006621] Duenas, Corina, 2017-05-17
created	[InstanceEdit:9020592] Duenas, Corina, 2017-09-07
dbId	9020591
displayName	Interleukin-12 signaling
edited	[InstanceEdit:9029257] Jupe, Steve, 2017-11-15
eventOf	[Pathway:R-HSA-447115] Interleukin-12 family signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1301067] interleukin-12-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-8950179] IL12B translocates from the cytosol to the extracellular region - Homo sapiens [Reaction:R-HSA-8950456] IL12B dimerizes - Homo sapiens [BlackBoxEvent:R-HSA-8950410] IL12B:IL12B translocates from ER lumen to the extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-8950113] IL12A binds IL12B - Homo sapiens [BlackBoxEvent:R-HSA-8950575] IL12A:IL12B translocates from ER lumen to Golgi - Homo sapiens [Reaction:R-HSA-8950752] IL12A:IL12B translocates from Golgi lumen to late endosome lumen - Homo sapiens [Reaction:R-HSA-8950347] IL12A:IL12B translocates from late endosome lumen to extracellular region - Homo sapiens [Reaction:R-HSA-8950057] IL12RB1 binds TYK2 - Homo sapiens [Reaction:R-HSA-8950063] IL12RB2 binds JAK2 - Homo sapiens [Reaction:R-HSA-447252] IL12RB1:TYK2 binds IL12RB2:JAK2 - Homo sapiens [Reaction:R-HSA-447226] Interleukin-12 binds Interleukin-12 receptor - Homo sapiens [Reaction:R-HSA-8950128] Interleukin-12 dissociates from Interleukin-12 receptor - Homo sapiens [BlackBoxEvent:R-HSA-8981093] IL12 bound to IL12R internalises - Homo sapiens [Reaction:R-HSA-8950423] JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated - Homo sapiens [BlackBoxEvent:R-HSA-8950757] IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated - Homo sapiens [Reaction:R-HSA-8950448] STAT4 binds to IL12RB2 in Interleukin-12 receptor complex - Homo sapiens [BlackBoxEvent:R-HSA-8950354] STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction - Homo sapiens [BlackBoxEvent:R-HSA-8952807] p-Y693-STAT4 dissociates after IL12:IL12R interaction - Homo sapiens [Reaction:R-HSA-8950778] p-Y693-STAT4 dimerizes - Homo sapiens [BlackBoxEvent:R-HSA-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Homo sapiens [Pathway:R-HSA-8950505] Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:9020695] The biology of IL-12: coordinating innate and adaptive immune responses
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interleukin-12 signaling
orthologousEvent	[Pathway:R-DDI-9020591] Interleukin-12 signaling - Dictyostelium discoideum [Pathway:R-CEL-9020591] Interleukin-12 signaling - Caenorhabditis elegans [Pathway:R-DME-9020591] Interleukin-12 signaling - Drosophila melanogaster [Pathway:R-GGA-9020591] Interleukin-12 signaling - Gallus gallus [Pathway:R-XTR-9020591] Interleukin-12 signaling - Xenopus tropicalis [Pathway:R-DRE-9020591] Interleukin-12 signaling - Danio rerio [Pathway:R-SSC-9020591] Interleukin-12 signaling - Sus scrofa [Pathway:R-BTA-9020591] Interleukin-12 signaling - Bos taurus [Pathway:R-CFA-9020591] Interleukin-12 signaling - Canis familiaris [Pathway:R-RNO-9020591] Interleukin-12 signaling - Rattus norvegicus [Pathway:R-MMU-9020591] Interleukin-12 signaling - Mus musculus
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28 [InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9020591
summation	[Summation:9020698] Interleukin 12 (IL-12) is heterodimeric cytokine produced by...
updateTrackers	[UpdateTracker:9775326] Update Tracker - [Pathway:9020591] Interleukin-12 signaling - v79:[updateIndirectRLE] [UpdateTracker:9778763] Update Tracker - [Pathway:9020591] Interleukin-12 signaling - v67:[updateContainedPathway] [UpdateTracker:9775932] Update Tracker - [Pathway:9020591] Interleukin-12 signaling - v78:[updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775326] Update Tracker - [Pathway:9020591] Interleukin-12 signaling - v79:[updateIndirectRLE] [UpdateTracker:9778763] Update Tracker - [Pathway:9020591] Interleukin-12 signaling - v67:[updateContainedPathway] [UpdateTracker:9775932] Update Tracker - [Pathway:9020591] Interleukin-12 signaling - v78:[updateIndirectRLE]
(hasEvent)	[Pathway:R-HSA-447115] Interleukin-12 family signaling

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