Reactome | STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction

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STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction Show undefined attributes

authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
catalystActivity	[CatalystActivity:8950536] transmembrane receptor protein tyrosine kinase activity of IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643963] transmembrane receptor protein tyrosine kinase activity of IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
dbId	8950354
displayName	STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
edited	[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
eventOf	[Pathway:R-HSA-9020591] Interleukin-12 signaling - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9006466] Stat4 is phosphorylated by p-Jak2 and/or p-Y-Tyk2 after Il12:Il12r interaction - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8950379] IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8950738] Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
output	[Complex:R-HSA-8952795] 2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8950354
summation	[Summation:8950348] Inferred from mouse: Signal transducer and activator of t...

Referrals

(hasEvent)	[Pathway:R-HSA-9020591] Interleukin-12 signaling
(inferredTo)	[BlackBoxEvent:R-MMU-9006466] Stat4 is phosphorylated by p-Jak2 and/or p-Y-Tyk2 after Il12:Il12r interaction

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