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Schema
>
BlackBoxEvent
>
Entries
IL12A binds IL12B
Show undefined attributes
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authored
[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
catalystActivity
[CatalystActivity:8950132] protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen]
catalystActivityReference
[CatalystActivityReference:9643625] protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen] The metallopeptide antibiotic bacitracin inhibits interleukin-12 alphabeta and beta2 secretion
category
uncertain
compartment
[Compartment:17957] endoplasmic reticulum lumen
created
[InstanceEdit:8950119] Duenas, Corina, 2016-12-02
dbId
8950113
displayName
IL12A binds IL12B
edited
[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
eventOf
[Pathway:R-HSA-9020591] Interleukin-12 signaling - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-8950139] IL12A [endoplasmic reticulum lumen]
[EntityWithAccessionedSequence:R-HSA-8950126] IL12B [endoplasmic reticulum lumen]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8950121] The metallopeptide antibiotic bacitracin inhibits interleukin-12 alphabeta and beta2 secretion
[LiteratureReference:8950127] Molecular characterization of interleukin 12
[LiteratureReference:447201] Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
IL12A binds IL12B
Interleukin-12 subunit alpha binds Interleukin-12 subunit beta by protein disulfide isomerase
orthologousEvent
[BlackBoxEvent:R-GGA-8950113] IL12A binds IL12B - Gallus gallus
[BlackBoxEvent:R-SSC-8950113] IL12A binds IL12B - Sus scrofa
[BlackBoxEvent:R-BTA-8950113] IL12A binds IL12B - Bos taurus
[BlackBoxEvent:R-CFA-8950113] IL12A binds IL12B - Canis familiaris
[BlackBoxEvent:R-RNO-8950113] IL12A binds IL12B - Rattus norvegicus
[BlackBoxEvent:R-MMU-8950113] IL12A binds IL12B - Mus musculus
output
[Complex:R-HSA-8950122] IL12A:IL12B [endoplasmic reticulum lumen]
releaseDate
2017-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-8950113
summation
[Summation:8950124] The Interleukin-12 heterodimer (IL-12) is formed by Interleu...
Referrals
(hasEvent)
[Pathway:R-HSA-9020591] Interleukin-12 signaling
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