Reactome | p-Y693-STAT4 dimer translocates to the nucleus

Schema > BlackBoxEvent > Entries

p-Y693-STAT4 dimer translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:8950030] Duenas, Corina, 2016-12-02
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:8950688] Duenas, Corina, 2016-12-02
dbId	8950181
displayName	p-Y693-STAT4 dimer translocates to the nucleus
edited	[InstanceEdit:9005965] Duenas, Corina, 2017-05-11
eventOf	[Pathway:R-HSA-9020591] Interleukin-12 signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8950389] Expression of Stress-70 protein, mitochondrial - Homo sapiens [BlackBoxEvent:R-HSA-8950581] Expression of Cofilin-1 - Homo sapiens [BlackBoxEvent:R-HSA-8950260] Expression of Proteasome activator complex subunit 2 - Homo sapiens [BlackBoxEvent:R-HSA-8950771] Expression of SOD1 - Homo sapiens [BlackBoxEvent:R-HSA-8950322] Expression of ribosomal protein lateral stalk subunit P0 - Homo sapiens [BlackBoxEvent:R-HSA-8950718] Expression of TCP1 - Homo sapiens [BlackBoxEvent:R-HSA-8950586] Expression of glutathione S-transferase alpha 2 - Homo sapiens [Reaction:R-HSA-9942511] STAT4 binds the TBX21 (T-bet) gene - Homo sapiens [BlackBoxEvent:R-HSA-8950344] Expression of BolA-like protein 2 - Homo sapiens [BlackBoxEvent:R-HSA-8950218] Expression of Moesin - Homo sapiens [BlackBoxEvent:R-HSA-8950732] Expression of Macrophage migration inhibitory factor - Homo sapiens [BlackBoxEvent:R-HSA-8950415] Expression of heterogeneous nuclear ribonucleoprotein F - Homo sapiens [BlackBoxEvent:R-HSA-8950721] Expression of Programmed cell death protein 4 - Homo sapiens [BlackBoxEvent:R-HSA-8950213] Expression of Phosphatidylinositol transfer protein alpha isoform - Homo sapiens [BlackBoxEvent:R-HSA-8950533] Expression of Ras-related protein Ral-A - Homo sapiens [BlackBoxEvent:R-HSA-8950681] Expression of Lamin-B1 - Homo sapiens [BlackBoxEvent:R-HSA-8950426] Expression of lymphocyte cytosolic protein 1 - Homo sapiens [BlackBoxEvent:R-HSA-8950684] Expression of Heterogeneous nuclear ribonucleoprotein D-like - Homo sapiens [BlackBoxEvent:R-HSA-8950173] Expression of ADP-ribosylation factor 1 - Homo sapiens [BlackBoxEvent:R-HSA-8950365] Expression of S-methyl-5'-thioadenosine phosphorylase - Homo sapiens [BlackBoxEvent:R-HSA-8950623] Expression of Carbonic anhydrase 1 - Homo sapiens [BlackBoxEvent:R-HSA-8950175] Expression of Glutathione S-transferase omega-1 - Homo sapiens [BlackBoxEvent:R-HSA-8950608] Expression U2 small nuclear ribonucleoprotein A' - Homo sapiens [BlackBoxEvent:R-HSA-8950480] Expression of annexin A2 - Homo sapiens [BlackBoxEvent:R-HSA-8950225] Expression of Ras-related protein Rap-1b - Homo sapiens [BlackBoxEvent:R-HSA-8950292] Expression of Heterogeneous nuclear ribonucleoproteins A2/B1 - Homo sapiens [BlackBoxEvent:R-HSA-8950634] Expression of capping actin protein of muscle Z-line alpha subunit 1 - Homo sapiens [BlackBoxEvent:R-HSA-8950314] Expression of calponin-2 - Homo sapiens [BlackBoxEvent:R-HSA-8950637] Expression of cell division cycle 42 - Homo sapiens [BlackBoxEvent:R-HSA-8950190] Expression of PAK2 - Homo sapiens [BlackBoxEvent:R-HSA-8950567] Expression of Plasminogen activator inhibitor 2 - Homo sapiens [BlackBoxEvent:R-HSA-8950328] Expression of Peptidyl-prolyl cis-trans isomerase A - Homo sapiens [BlackBoxEvent:R-HSA-8950201] Expression of Aryl Hydrocarbon receptor-interacting protein - Homo sapiens
input	[Complex:R-HSA-8950602] p-Y693-STAT4 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8950738] Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling [LiteratureReference:8950667] Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	p-Y693-STAT4 dimer translocates to the nucleus
orthologousEvent	[BlackBoxEvent:R-MMU-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Mus musculus [BlackBoxEvent:R-CFA-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Canis familiaris [BlackBoxEvent:R-BTA-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Bos taurus [BlackBoxEvent:R-SSC-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Sus scrofa [BlackBoxEvent:R-DRE-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Danio rerio [BlackBoxEvent:R-XTR-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Xenopus tropicalis [BlackBoxEvent:R-GGA-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Gallus gallus [BlackBoxEvent:R-DME-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Drosophila melanogaster [BlackBoxEvent:R-CEL-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DDI-8950181] p-Y693-STAT4 dimer translocates to the nucleus - Dictyostelium discoideum
output	[Complex:R-HSA-8950759] p-Y693-STAT4 dimer [nucleoplasm]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9006071] van de Vosse, Esther, 2017-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8950181
summation	[Summation:8950641] Once activated by tyrosine phosphorylation, Signal transduce...

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[Pathway:R-HSA-9020591] Interleukin-12 signaling

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