activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

Stable Identifier
R-HSA-9013891
Type
Complex
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
16115877 Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

Cusson-Hermance, N, Khurana, S, Lee, TH, Fitzgerald, KA, Kelliher, MA

J Biol Chem 2005
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Kaiser, WJ, Offermann, MK

J Immunol 2005
22421964 dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Estornes, Y, Toscano, F, Virard, F, Jacquemin, G, Pierrot, A, Vanbervliet, B, Bonnin, M, Lalaoui, N, Mercier-Gouy, P, Pachéco, Y, Salaun, B, Renno, T, Micheau, O, Lebecque, S

Cell Death Differ. 2012
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Feoktistova, M, Geserick, P, Kellert, B, Dimitrova, DP, Langlais, C, Hupe, M, Cain, K, MacFarlane, M, Häcker, G, Leverkus, M

Mol. Cell 2011
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