Reactome | STAT1 binds HEY1 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9021336] Orlic-Milacic, Marija, 2017-09-18
dbId	9021334
displayName	STAT1 binds HEY1 gene promoter
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9014129] HEY1 gene expression is positively regulated by NOTCH3 and STAT1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20142] positive regulation of transcription of Notch receptor target
input	[EntityWithAccessionedSequence:R-HSA-4396358] HEY1 gene [nucleoplasm] [Complex:R-HSA-6788626] p-Y701-STAT1 dimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9021321] Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STAT1 binds HEY1 gene promoter
output	[Complex:R-HSA-9021333] p-Y701-STAT1 dimer:HEY1 gene [nucleoplasm]
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9021334
summation	[Summation:9021335] STAT1 can bind to STAT response elements in the HEY1 gene pr...

(hasEvent)	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9014129] HEY1 gene expression is positively regulated by NOTCH3 and STAT1

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