Reactome | ER Quality Control Compartment (ERQC)

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ER Quality Control Compartment (ERQC) Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
created	[InstanceEdit:901079] Jassal, B, 2010-07-02
dbId	901032
displayName	ER Quality Control Compartment (ERQC)
edited	[InstanceEdit:901079] Jassal, B, 2010-07-02
eventOf	[Pathway:R-HSA-901042] Calnexin/calreticulin cycle - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6792151] endoplasmic reticulum mannose trimming
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-901074] MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) - Homo sapiens [Reaction:R-HSA-901039] MAN1B1 hydrolyses 1,2-linked mannose (c branch) - Homo sapiens [Reaction:R-HSA-901024] MAN1B1 hydrolyses 1,2-linked mannose (a branch) - Homo sapiens [Reaction:R-HSA-901036] MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) - Homo sapiens [Reaction:R-HSA-548884] UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b - Homo sapiens [BlackBoxEvent:R-HSA-6782685] EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 - Homo sapiens [Reaction:R-HSA-8867288] OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 - Homo sapiens [BlackBoxEvent:R-HSA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Homo sapiens [Reaction:R-HSA-1017228] Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[LiteratureReference:901058] Glycoprotein folding, quality control and ER-associated degradation [LiteratureReference:947814] A novel quality control compartment derived from the endoplasmic reticulum [LiteratureReference:947811] Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation [LiteratureReference:947808] Protein quality control in the ER: the recognition of misfolded proteins
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ER Quality Control Compartment (ERQC)
orthologousEvent	[Pathway:R-PFA-901032] ER Quality Control Compartment (ERQC) - Plasmodium falciparum [Pathway:R-DDI-901032] ER Quality Control Compartment (ERQC) - Dictyostelium discoideum [Pathway:R-CEL-901032] ER Quality Control Compartment (ERQC) - Caenorhabditis elegans [Pathway:R-DME-901032] ER Quality Control Compartment (ERQC) - Drosophila melanogaster [Pathway:R-GGA-901032] ER Quality Control Compartment (ERQC) - Gallus gallus [Pathway:R-XTR-901032] ER Quality Control Compartment (ERQC) - Xenopus tropicalis [Pathway:R-DRE-901032] ER Quality Control Compartment (ERQC) - Danio rerio [Pathway:R-SSC-901032] ER Quality Control Compartment (ERQC) - Sus scrofa [Pathway:R-BTA-901032] ER Quality Control Compartment (ERQC) - Bos taurus [Pathway:R-CFA-901032] ER Quality Control Compartment (ERQC) - Canis familiaris [Pathway:R-RNO-901032] ER Quality Control Compartment (ERQC) - Rattus norvegicus [Pathway:R-MMU-901032] ER Quality Control Compartment (ERQC) - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1028799] Gagneux, P, 2010-11-18
revised	[InstanceEdit:6781873] Jassal, Bijay, 2015-06-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-901032
summation	[Summation:901023] Proteins that are released from the CNX or CRT complex with ...
updateTrackers	[UpdateTracker:9783717] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v56:[updateContainedRLE] [UpdateTracker:9786875] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v47:[modifyText] [UpdateTracker:9782559] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v59:[updateContainedRLE] [UpdateTracker:9783231] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v57:[addHasEvent, updateContainedRLE] [UpdateTracker:9789832] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v37:[modifyText] [UpdateTracker:9784400] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v54:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9777662] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v69:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9783717] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v56:[updateContainedRLE]
[UpdateTracker:9786875] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v47:[modifyText]
[UpdateTracker:9782559] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v59:[updateContainedRLE]
[UpdateTracker:9783231] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v57:[addHasEvent, updateContainedRLE]
[UpdateTracker:9789832] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v37:[modifyText]
[UpdateTracker:9784400] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v54:[add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9777662] Update Tracker - [Pathway:901032] ER Quality Control Compartment (ERQC) - v69:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-901042] Calnexin/calreticulin cycle

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