Reactome | MAN1B1 hydrolyses 1,2-linked mannose (c branch)

Schema > Reaction > Entries

MAN1B1 hydrolyses 1,2-linked mannose (c branch) Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:901026] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]
category	transition
compartment	[Compartment:927893] endoplasmic reticulum quality control compartment
created	[InstanceEdit:901079] Jassal, B, 2010-07-02
dbId	901039
diseaseReaction	[FailedReaction:R-HSA-9036012] Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) - Homo sapiens
displayName	MAN1B1 hydrolyses 1,2-linked mannose (c branch)
edited	[InstanceEdit:901079] Jassal, B, 2010-07-02
eventOf	[Pathway:R-HSA-901032] ER Quality Control Compartment (ERQC) - Homo sapiens
figure	[Figure:1028826] /figures/man8c.png
followingEvent	[Reaction:R-HSA-548884] UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b - Homo sapiens [Reaction:R-HSA-947991] Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6791834] trimming of terminal mannose on C branch
input	[Complex:R-HSA-912283] (un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] [SimpleEntity:R-ALL-6781870] H2O [endoplasmic reticulum quality control compartment]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1018373] Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis [LiteratureReference:947811] Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation [LiteratureReference:6781871] Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAN1B1 hydrolyses 1,2-linked mannose (c branch) Trimming of the terminal mannose on the C branch
output	[SimpleEntity:R-ALL-912281] Man [endoplasmic reticulum quality control compartment] [Complex:R-HSA-912295] unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1028799] Gagneux, P, 2010-11-18
revised	[InstanceEdit:6781873] Jassal, Bijay, 2015-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-901039
summation	[Summation:948025] The enzyme ER Man I can slowly trim up to four of the mannos...
updateTrackers	[UpdateTracker:9784361] Update Tracker - [Reaction:901039] MAN1B1 hydrolyses 1,2-linked mannose (c branch) - v54:[addInput, add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784361] Update Tracker - [Reaction:901039] MAN1B1 hydrolyses 1,2-linked mannose (c branch) - v54:[addInput, add_removeLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-9036012] Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)
(precedingEvent)	[Reaction:R-HSA-947991] Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi [Reaction:R-HSA-548884] UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b
(hasEvent)	[Pathway:R-HSA-901032] ER Quality Control Compartment (ERQC)