Reactome | UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b

Schema > Reaction > Entries

UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:548875] UDP-glucose:glycoprotein glucosyltransferase activity of UGGT1,2 [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:927893] endoplasmic reticulum quality control compartment
created	[InstanceEdit:548900] Jassal, B, 2010-03-15
dbId	548884
displayName	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b
edited	[InstanceEdit:548900] Jassal, B, 2010-03-15
eventOf	[Pathway:R-HSA-901032] ER Quality Control Compartment (ERQC) - Homo sapiens
figure	[Figure:1028827] /figures/man9glc1.png
followingEvent	[Reaction:R-HSA-1017228] Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex - Homo sapiens
input	[SimpleEntity:R-ALL-912292] DbGP [endoplasmic reticulum quality control compartment] [Complex:R-HSA-912284] unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:548905] Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity [LiteratureReference:548854] The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain [LiteratureReference:1018367] A cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b Re-addition of a glucose on the alpha 1,3 branch
output	[SimpleEntity:R-ALL-912287] DOLP [endoplasmic reticulum quality control compartment] [Complex:R-HSA-6781883] unfolded protein:(Glc)1 (GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment]
precedingEvent	[Reaction:R-HSA-901074] MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) - Homo sapiens [Reaction:R-HSA-901039] MAN1B1 hydrolyses 1,2-linked mannose (c branch) - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1028799] Gagneux, P, 2010-11-18
revised	[InstanceEdit:6781873] Jassal, Bijay, 2015-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-548884
summation	[Summation:1018366] The UDP-glucose:glycoprotein glucosyltransferases 1 and 2 (U...
updateTrackers	[UpdateTracker:9784336] Update Tracker - [Reaction:548884] UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b - v54:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784336] Update Tracker - [Reaction:548884] UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b - v54:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-901032] ER Quality Control Compartment (ERQC)
(precedingEvent)	[Reaction:R-HSA-1017228] Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex

Cite Us!