Reactome | Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol

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Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol Show undefined attributes

authored	[InstanceEdit:1022125] Jassal, B, 2010-11-17
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:927893] endoplasmic reticulum quality control compartment
created	[InstanceEdit:1022125] Jassal, B, 2010-11-17
dbId	1022127
displayName	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol
edited	[InstanceEdit:1022125] Jassal, B, 2010-11-17
eventOf	[Pathway:R-HSA-901032] ER Quality Control Compartment (ERQC) - Homo sapiens
followingEvent	[Reaction:R-HSA-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins - Homo sapiens [Reaction:R-HSA-8853379] ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) - Homo sapiens
input	[Complex:R-HSA-8867287] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359168] OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD [LiteratureReference:6782695] A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal [LiteratureReference:6782701] Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins [LiteratureReference:6781877] The mammalian endoplasmic reticulum-associated degradation system
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol Glycoproteins with major folding defects are sent to degradation by OS9:SEL1:SYVN1 dimer:DERL2
orthologousEvent	[BlackBoxEvent:R-PFA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Plasmodium falciparum [BlackBoxEvent:R-DDI-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Dictyostelium discoideum [BlackBoxEvent:R-CEL-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Caenorhabditis elegans [BlackBoxEvent:R-DME-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Drosophila melanogaster [BlackBoxEvent:R-GGA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Gallus gallus [BlackBoxEvent:R-XTR-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Danio rerio [BlackBoxEvent:R-SSC-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Sus scrofa [BlackBoxEvent:R-BTA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Bos taurus [BlackBoxEvent:R-CFA-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Canis familiaris [BlackBoxEvent:R-RNO-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Rattus norvegicus [BlackBoxEvent:R-MMU-1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - Mus musculus
output	[Complex:R-HSA-8866894] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]
precedingEvent	[Reaction:R-HSA-8867288] OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6784606] Dall'Olio, Giovanni, 2015-06-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1022127
summation	[Summation:9645348] Proteins with major folding defects are extracted from futil...
updateTrackers	[UpdateTracker:9777673] Update Tracker - [BlackBoxEvent:1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - v69:[add_removeSummation, removeCatalystActivity] [UpdateTracker:9783219] Update Tracker - [BlackBoxEvent:1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - v57:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9783470] Update Tracker - [BlackBoxEvent:1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - v56:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9777673] Update Tracker - [BlackBoxEvent:1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - v69:[add_removeSummation, removeCatalystActivity] [UpdateTracker:9783219] Update Tracker - [BlackBoxEvent:1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - v57:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9783470] Update Tracker - [BlackBoxEvent:1022127] Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol - v56:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-901032] ER Quality Control Compartment (ERQC)
(precedingEvent)	[Reaction:R-HSA-8850594] Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins [Reaction:R-HSA-8853379] ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

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