Reactome | Thrombin-activated PARs:G12/13 (active) dissociate

authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:397892] Jupe, S, 2009-03-13 15:58:15
dbId	397891
displayName	Thrombin-activated PARs:G12/13 (active) dissociate
edited	[InstanceEdit:870306] Jupe, S, 2010-06-07
eventOf	[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Homo sapiens
followingEvent	[Reaction:R-HSA-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Homo sapiens [Reaction:R-HSA-398184] LARG activation by G alpha 12/13 - Homo sapiens [Reaction:R-HSA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Homo sapiens [Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Homo sapiens [Reaction:R-HSA-392295] Gbeta:gamma recruits PI3K gamma - Homo sapiens [Reaction:R-HSA-398040] Gbeta:gamma activation of PLC beta - Homo sapiens [Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Homo sapiens
input	[Complex:R-HSA-397884] Thrombin activated PAR:G12/13 (active) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Thrombin-activated PARs:G12/13 (active) dissociate
orthologousEvent	[Reaction:R-CEL-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Caenorhabditis elegans [Reaction:R-GGA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Gallus gallus [Reaction:R-BTA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Bos taurus [Reaction:R-CFA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Canis familiaris [Reaction:R-MMU-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Mus musculus
output	[DefinedSet:R-HSA-418572] G-protein alpha (12/13):GTP [plasma membrane] 2 × [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] [DefinedSet:R-HSA-114530] Thrombin-activated PARs [plasma membrane]
precedingEvent	[Reaction:R-HSA-114552] Thrombin-activated PARs activate G12/13 - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870306] Jupe, S, 2010-06-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-397891
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...

Thrombin-activated PARs:G12/13 (active) dissociate Show undefined attributes

Referrals