CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex

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R-HSA-8961619
Type
Reaction [omitted]
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Homo sapiens
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E2F1 directly stimulates transcription of the CDC6 gene (Yan et al., 1998; Ohtani et al., 1998). CDC6 is required to recruit the MCM2-7 replication helicases.
Transcription of the CDC6 gene is directly repressed by the DREAM complex (Litovchick et al. 2007).

Literature References
PubMed ID Title Journal Year
9520412 Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

Yan, Z, DeGregori, J, Shohet, R, Leone, G, Stillman, B, Nevins, JR, Williams, RS

Proc Natl Acad Sci U S A 1998
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Tsujimoto, A, Ikeda, M, Nakamura, M

Oncogene 1998
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

Litovchick, L, Sadasivam, S, Florens, LA, Zhu, X, Swanson, SK, Velmurugan, S, Chen, R, Washburn, MP, Liu, XS, DeCaprio, JA

Mol Cell 2007
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