CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex

Stable Identifier
Reaction [omitted]
Homo sapiens
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E2F1 directly stimulates transcription of the CDC6 gene (Yan et al., 1998; Ohtani et al., 1998). CDC6 is required to recruit the MCM2-7 replication helicases.
Transcription of the CDC6 gene is directly repressed by the DREAM complex (Litovchick et al. 2007).

Literature References
PubMed ID Title Journal Year
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Ikeda, M, Nakamura, M, Tsujimoto, A

Oncogene 1998
9520412 Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

Leone, G, Williams, RS, Nevins, JR, DeGregori, J, Stillman, B, Shohet, R, Yan, Z

Proc Natl Acad Sci U S A 1998
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

DeCaprio, JA, Washburn, MP, Swanson, SK, Zhu, X, Florens, LA, Chen, R, Litovchick, L, Liu, XS, Sadasivam, S, Velmurugan, S

Mol Cell 2007
This event is regulated
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