Reactome | SEPHS2 phosphorylates H2Se to form SELP

Schema > Reaction > Entries

SEPHS2 phosphorylates H2Se to form SELP Show undefined attributes

authored	[InstanceEdit:8959515] Jassal, Bijay, 2017-01-26
catalystActivity	[CatalystActivity:8959517] selenide, water dikinase activity of SEPHS2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8959515] Jassal, Bijay, 2017-01-26
crossReference	[DatabaseIdentifier:12667931] RHEA:18738 [DatabaseIdentifier:9930604] RHEA:18738
dbId	8959510
displayName	SEPHS2 phosphorylates H2Se to form SELP
edited	[InstanceEdit:8959515] Jassal, Bijay, 2017-01-26
eventOf	[Pathway:R-HSA-2408557] Selenocysteine synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5357660] selanide [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8959509] Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SEPHS2 phosphorylates H2Se to form SELP ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate
orthologousEvent	[Reaction:R-RNO-8959510] SEPHS2 phosphorylates H2Se to form SELP - Rattus norvegicus [Reaction:R-PFA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Plasmodium falciparum [Reaction:R-DDI-8959510] SEPHS2 phosphorylates H2Se to form SELP - Dictyostelium discoideum [Reaction:R-CEL-8959510] SEPHS2 phosphorylates H2Se to form SELP - Caenorhabditis elegans [Reaction:R-DME-8959510] SEPHS2 phosphorylates H2Se to form SELP - Drosophila melanogaster [Reaction:R-GGA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Gallus gallus [Reaction:R-DRE-8959510] SEPHS2 phosphorylates H2Se to form SELP - Danio rerio [Reaction:R-SSC-8959510] SEPHS2 phosphorylates H2Se to form SELP - Sus scrofa [Reaction:R-CFA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Canis familiaris [Reaction:R-MMU-8959510] SEPHS2 phosphorylates H2Se to form SELP - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-8959518] SELP [cytosol]
precedingEvent	[Reaction:R-HSA-2408500] GSSeH condenses with GSH to form H2Se and GSSG - Homo sapiens [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase - Homo sapiens [Reaction:R-HSA-2408558] SeO3(2-) is reduced to H2Se by TXNRD1 - Homo sapiens [Reaction:R-HSA-2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959643] D'Eustachio, Peter, 2017-01-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8959510
summation	[Summation:8959523] Selenoproteins are proteins that incorporate the nonstandard...

Referrals

(hasEvent)	[Pathway:R-HSA-2408557] Selenocysteine synthesis
(precedingEvent)	[Reaction:R-HSA-2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer