Reactome | GSSeH condenses with GSH to form H2Se and GSSG

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GSSeH condenses with GSH to form H2Se and GSSG Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408500
displayName	GSSeH condenses with GSH to form H2Se and GSSG
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408550] Metabolism of ingested H2SeO4 and H2SeO3 into H2Se - Homo sapiens
followingEvent	[Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Homo sapiens [Reaction:R-HSA-2408536] H2Se is methylated to MeSeH by H2Se methyltransferase - Homo sapiens
inferredFrom	[Reaction:R-RNO-2408520] GSSeH condenses with GSH to form H2Se and GSSG - Rattus norvegicus
input	[SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-5357664] GSSeH [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5359357] Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GSSeH condenses with GSH to form H2Se and GSSG
output	[SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-5357660] selanide [cytosol]
precedingEvent	[Reaction:R-HSA-2408542] GSSeSG is reduced to GSSeH and GSH by GSR - Homo sapiens [BlackBoxEvent:R-HSA-5333608] GSSebGalNac is reduced and methylated to MeSebGalNac - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2408500
summation	[Summation:5422898] Gluthathioselenol (GSSeH) and reduced glutathione (GSH) cond...

Referrals

(hasEvent)	[Pathway:R-HSA-2408550] Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
(precedingEvent)	[Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP [Reaction:R-HSA-2408536] H2Se is methylated to MeSeH by H2Se methyltransferase
(inferredTo)	[Reaction:R-RNO-2408520] GSSeH condenses with GSH to form H2Se and GSSG

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