Reactome | Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer

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Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359092] O-phosphoseryl-tRNA(Sec) selenium transferase activity of PXLP-K284-SEPSECS tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
crossReference	[DatabaseIdentifier:9930620] RHEA:25042
dbId	2408555
displayName	Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408557] Selenocysteine synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2408509] Sec-tRNA(Sec) binds to EEFSEC:GTP - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-8959518] SELP [cytosol] [GenomeEncodedEntity:R-HSA-5357712] Sep-tRNA(Sec) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359353] The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation [LiteratureReference:5359373] RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea
maxDepth	1
modified	[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate
output	2 × [SimpleEntity:R-ALL-29372] Pi [cytosol] [GenomeEncodedEntity:R-HSA-5357708] Sec-tRNA(Sec) [cytosol]
precedingEvent	[Reaction:R-HSA-2408507] Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK - Homo sapiens [Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2408555
summation	[Summation:5359365] O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS) tetr...
updateTrackers	[UpdateTracker:9776904] Update Tracker - [Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer - v74:[add_removeOutput] [UpdateTracker:9781679] Update Tracker - [Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer - v60:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776904] Update Tracker - [Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer - v74:[add_removeOutput] [UpdateTracker:9781679] Update Tracker - [Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer - v60:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-2408557] Selenocysteine synthesis
(precedingEvent)	[Reaction:R-HSA-2408509] Sec-tRNA(Sec) binds to EEFSEC:GTP

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