Reactome | SeO3(2-) is reduced to H2Se by TXNRD1

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SeO3(2-) is reduced to H2Se by TXNRD1 Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359081] selenite reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408558
displayName	SeO3(2-) is reduced to H2Se by TXNRD1
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408550] Metabolism of ingested H2SeO4 and H2SeO3 into H2Se - Homo sapiens
followingEvent	[Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Homo sapiens [Reaction:R-HSA-2408536] H2Se is methylated to MeSeH by H2Se methyltransferase - Homo sapiens
inferredFrom	[Reaction:R-BTA-2408527] SeO3(2-) is reduced to H2Se by TXNRD1 - Bos taurus
input	3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-5357720] SeO3(2-) [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5359344] Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases [LiteratureReference:5359340] Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SeO3(2-) is reduced to H2Se by TXNRD1
output	3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-5357660] selanide [cytosol]
precedingEvent	[Reaction:R-HSA-2408548] PAPSe is reduced to SeO3(2-) by PAPSe reductase - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2408558
summation	[Summation:5422895] Thioredoxin reductase 1 (TXNRD1) homodimer (Sun et al. 1999)...

Referrals

(hasEvent)	[Pathway:R-HSA-2408550] Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
(precedingEvent)	[Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP [Reaction:R-HSA-2408536] H2Se is methylated to MeSeH by H2Se methyltransferase
(inferredTo)	[Reaction:R-BTA-2408527] SeO3(2-) is reduced to H2Se by TXNRD1

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