Reactome | SEPHS2 phosphorylates H2Se to form SELP

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SEPHS2 phosphorylates H2Se to form SELP Show undefined attributes

catalystActivity	[CatalystActivity:10900544] selenide, water dikinase activity of SEPHS2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10900546
displayName	SEPHS2 phosphorylates H2Se to form SELP
eventOf	[Pathway:R-DME-2408557] Selenocysteine synthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5357660] selanide [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SEPHS2 phosphorylates H2Se to form SELP ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-8959518] SELP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8959510
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2408557] Selenocysteine synthesis
(inferredTo)	[Reaction:R-HSA-8959510] SEPHS2 phosphorylates H2Se to form SELP

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