Reactome | PRODH2 oxidises HPRO to 1PYR-3OH-5COOH

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PRODH2 oxidises HPRO to 1PYR-3OH-5COOH Show undefined attributes

authored	[InstanceEdit:8955818] Jassal, Bijay, 2017-01-13
catalystActivity	[CatalystActivity:8955819] proline dehydrogenase activity of PRODH2 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8955818] Jassal, Bijay, 2017-01-13
crossReference	[DatabaseIdentifier:9929444] RHEA:52513
dbId	8955817
displayName	PRODH2 oxidises HPRO to 1PYR-3OH-5COOH
edited	[InstanceEdit:8955818] Jassal, Bijay, 2017-01-13
eventOf	[Pathway:R-HSA-70688] Proline catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Homo sapiens [Reaction:R-HSA-70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS - Homo sapiens
input	[SimpleEntity:R-ALL-113597] FAD [mitochondrial inner membrane] [SimpleEntity:R-ALL-6784215] HPRO [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6784230] Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PRODH2 oxidises HPRO to 1PYR-3OH-5COOH a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
orthologousEvent	[Reaction:R-SCE-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Saccharomyces cerevisiae [Reaction:R-SPO-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Schizosaccharomyces pombe [Reaction:R-DDI-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Dictyostelium discoideum [Reaction:R-CEL-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Caenorhabditis elegans [Reaction:R-DME-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Drosophila melanogaster [Reaction:R-GGA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Gallus gallus [Reaction:R-XTR-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Xenopus tropicalis [Reaction:R-DRE-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Danio rerio [Reaction:R-SSC-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Sus scrofa [Reaction:R-BTA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Bos taurus [Reaction:R-CFA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Canis familiaris [Reaction:R-RNO-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Rattus norvegicus [Reaction:R-MMU-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Mus musculus
output	[SimpleEntity:R-ALL-9929425] 1PYR-3OH-5COOH [mitochondrial matrix] [SimpleEntity:R-ALL-164934] FADH2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959643] D'Eustachio, Peter, 2017-01-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8955817
summation	[Summation:8955829] HPRO (4-hydroxy-L-proline) is oxidized to 1PYR-3OH-5COOH (L-...
updateTrackers	[UpdateTracker:9939798] Update Tracker - [Reaction:8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - v92:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939798] Update Tracker - [Reaction:8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - v92:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-70688] Proline catabolism
(precedingEvent)	[Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-HSA-70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS