Reactome | Proline catabolism

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Proline catabolism Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
compartment	[Compartment:5462] mitochondrion
dbId	70688
deleted	[Deleted:508095] Deletion of instance: 70694 [Deleted:9640344] Deletion of instance: 70614 [Deleted:507853] Deletion of instance: 70693 [Deleted:9640342] Deletion of instance: 6788656
displayName	Proline catabolism
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:10931] L-proline catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-70670] PRODH oxidises L-Pro to 1PYR-5COOH - Homo sapiens [Reaction:R-HSA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Homo sapiens [Reaction:R-HSA-70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS - Homo sapiens [Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Homo sapiens [Reaction:R-HSA-70679] ALDH4A1 oxidises L-GluSS to Glu - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[Book:70661] Disorders of proline and hydroxyproline metabolism 0079130356 Scriver, Charles R The Metabolic and Molecular Bases of Inherited Disease, 8th ed
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Proline catabolism
orthologousEvent	[Pathway:R-RNO-70688] Proline catabolism - Rattus norvegicus [Pathway:R-SCE-70688] Proline catabolism - Saccharomyces cerevisiae [Pathway:R-SPO-70688] Proline catabolism - Schizosaccharomyces pombe [Pathway:R-DDI-70688] Proline catabolism - Dictyostelium discoideum [Pathway:R-CEL-70688] Proline catabolism - Caenorhabditis elegans [Pathway:R-DME-70688] Proline catabolism - Drosophila melanogaster [Pathway:R-GGA-70688] Proline catabolism - Gallus gallus [Pathway:R-XTR-70688] Proline catabolism - Xenopus tropicalis [Pathway:R-DRE-70688] Proline catabolism - Danio rerio [Pathway:R-SSC-70688] Proline catabolism - Sus scrofa [Pathway:R-BTA-70688] Proline catabolism - Bos taurus [Pathway:R-CFA-70688] Proline catabolism - Canis familiaris [Pathway:R-MMU-70688] Proline catabolism - Mus musculus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2003-05-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939375] Hill, David P, 2025-02-25
revised	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-70688
summation	[Summation:213118] Proline is catabolized in two steps to yield L-glutamate gam...
updateTrackers	[UpdateTracker:9781941] Update Tracker - [Pathway:70688] Proline catabolism - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9790930] Update Tracker - [Pathway:70688] Proline catabolism - v32:[addLiteratureReference, modifyText, removeHasEvent, updateContainedRLE] [UpdateTracker:9792347] Update Tracker - [Pathway:70688] Proline catabolism - v22:[updateContainedRLE] [UpdateTracker:9790380] Update Tracker - [Pathway:70688] Proline catabolism - v33:[updateContainedRLE] [UpdateTracker:9792083] Update Tracker - [Pathway:70688] Proline catabolism - v24:[addSummation] [UpdateTracker:9939811] Update Tracker - [Pathway:70688] Proline catabolism - v92:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9781941] Update Tracker - [Pathway:70688] Proline catabolism - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9790930] Update Tracker - [Pathway:70688] Proline catabolism - v32:[addLiteratureReference, modifyText, removeHasEvent, updateContainedRLE] [UpdateTracker:9792347] Update Tracker - [Pathway:70688] Proline catabolism - v22:[updateContainedRLE] [UpdateTracker:9790380] Update Tracker - [Pathway:70688] Proline catabolism - v33:[updateContainedRLE] [UpdateTracker:9792083] Update Tracker - [Pathway:70688] Proline catabolism - v24:[addSummation] [UpdateTracker:9939811] Update Tracker - [Pathway:70688] Proline catabolism - v92:[removeHasEvent]
(replacementInstances)	[Deleted:507853] Deletion of instance: 70693 [Deleted:508095] Deletion of instance: 70694 [Deleted:9640344] Deletion of instance: 70614 [Deleted:9640342] Deletion of instance: 6788656
(hasEvent)	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives

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